NeuroMotor PenTM Report

Published

March 15, 2023

Parkinson’s Disease Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC043
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-30 14:53
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment OLD PATIENT MADOPAR 3X1\4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 7 individuals with a value less than 0.53 were subsequently diagnosed with PD. That is, 16.67% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.53 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 2, 'TN': 2, 'TP': 40, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 23, 'TN': 13, 'TP': 19, 'FP': 17}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 16, 'TN': 10, 'TP': 26, 'FP': 20}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 12.004
timePerCircleCoV 0.120785
timePerCircleSlope 0.0171458
meanError 1.18571
tremorFreq 6.34766
tremorRelPower 32.9986
tremorGyroAmpMean 0.0500778
tremorGyroAmpSlope -0.000798128
tremorGyroAmpCoV 0.416055
tremorCoordAmpMean 0.0644547
tremorCoordAmpSlope -0.00347977
tremorCoordAmpCoV 0.349037
tremorAccAmpMean 0.0669529
tremorAccAmpSlope -0.00118171
tremorAccAmpCoV 0.21085
tremorPcRelVar 0.783211
tremorPcX 0.694557
tremorPcY 0.719437

Circle Segment 1

Duration 10.48 s, Accuracy Estimate 0.955 (lower is better)

Circle Segment 2

Duration 10.4 s, Accuracy Estimate 1.518 (lower is better)

Circle Segment 3

Duration 10.6 s, Accuracy Estimate 1.351 (lower is better)

Circle Segment 4

Duration 11.8 s, Accuracy Estimate 0.832 (lower is better)

Circle Segment 5

Duration 13.0 s, Accuracy Estimate 0.992 (lower is better)

Circle Segment 6

Duration 13.64 s, Accuracy Estimate 1.056 (lower is better)

Circle Segment 7

Duration 14.08 s, Accuracy Estimate 0.916 (lower is better)

Circle Segment 8

Duration 13.44 s, Accuracy Estimate 1.361 (lower is better)

Circle Segment 9

Duration 12.0 s, Accuracy Estimate 0.852 (lower is better)

Circle Segment 10

Duration 10.6 s, Accuracy Estimate 2.024 (lower is better)

Spiral

numSpirals 7
timePerSpiralMean 36.4514
timePerSpiralCoV 0.0438287
timePerSpiralSlope 0.000195955
meanError 1.64055
tremorFreq 5.95703
tremorRelPower 30.1963
tremorGyroAmpMean 0.0592357
tremorGyroAmpSlope 0.00022891
tremorGyroAmpCoV 0.446323
tremorCoordAmpMean 0.0825926
tremorCoordAmpSlope 5.46527e-05
tremorCoordAmpCoV 0.392851
tremorAccAmpMean 0.0698481
tremorAccAmpSlope 1.08464e-05
tremorAccAmpCoV 0.38467
tremorPcRelVar 0.777436
tremorPcX -0.635894
tremorPcY -0.771776

Spiral Segment 1

Duration 36.16 s, Accuracy Estimate 1.69 (lower is better)

Spiral Segment 2

Duration 39.04 s, Accuracy Estimate 1.501 (lower is better)

Spiral Segment 3

Duration 34.64 s, Accuracy Estimate 1.57 (lower is better)

Spiral Segment 4

Duration 34.6 s, Accuracy Estimate 1.744 (lower is better)

Spiral Segment 5

Duration 36.48 s, Accuracy Estimate 1.65 (lower is better)

Spiral Segment 6

Duration 37.8 s, Accuracy Estimate 1.672 (lower is better)

Spiral Segment 7

Duration 36.44 s, Accuracy Estimate 1.657 (lower is better)

Elel

eDurationMean 0.660541
eDurationStd 0.085552
eDurationStdnorm 0.129518
eDurationMedian 0.65
eDurationQuartdelta 0.0775
eDurationQuartdeltanorm 0.119231
eDurationKurt 3.99314
eDurationTrenddiff 0.0225
eDurationTrendratio 1.03475
eWidthMean 7.54808
eWidthStd 1.89755
eWidthStdnorm 0.251394
eWidthMedian 7.722
eWidthQuartdelta 2.5155
eWidthQuartdeltanorm 0.325758
eWidthKurt 2.79355
eWidthTrenddiff -0.1755
eWidthTrendratio 0.977273
eHeightMean 12.9143
eHeightStd 3.275
eHeightStdnorm 0.253595
eHeightMedian 12.87
eHeightQuartdelta 2.9835
eHeightQuartdeltanorm 0.231818
eHeightKurt 9.5605
eHeightTrenddiff -0.7605
eHeightTrendratio 0.941176
eAspectMean 0.598029
eAspectStd 0.138572
eAspectStdnorm 0.231715
eAspectMedian 0.614035
eAspectQuartdelta 0.188732
eAspectQuartdeltanorm 0.307364
eAspectKurt 2.89746
eAspectTrenddiff 0.0256765
eAspectTrendratio 1.0426
eSlantMean 0.142398
eSlantStd 0.23381
eSlantStdnorm 1.64195
eSlantMedian 0.129032
eSlantQuartdelta 0.265937
eSlantQuartdeltanorm 2.06101
eSlantKurt 3.95093
eSlantTrenddiff -0.0168236
eRtopMean 0.805337
eRtopStd 0.139722
eRtopStdnorm 0.173495
eRtopMedian 0.836066
eRtopQuartdelta 0.210905
eRtopQuartdeltanorm 0.252259
eRtopKurt 2.60373
eRtopTrenddiff 0.0570631
eRbotMean 0.591727
eRbotStd 0.252882
eRbotStdnorm 0.427362
eRbotMedian 0.636364
eRbotQuartdelta 0.368703
eRbotQuartdeltanorm 0.579391
eRbotKurt 2.68723
eRbotTrenddiff -0.0586468
eRrightMean 0.897784
eRrightStd 0.0776911
eRrightStdnorm 0.0865365
eRrightMedian 0.914286
eRrightQuartdelta 0.0862346
eRrightQuartdeltanorm 0.0943191
eRrightKurt 3.5446
eRrightTrenddiff 0.035339
eRleftMean 0.3285
eRleftStd 0.139706
eRleftStdnorm 0.425285
eRleftMedian 0.302521
eRleftQuartdelta 0.14641
eRleftQuartdeltanorm 0.483967
eRleftKurt 3.12329
eRleftTrenddiff -0.0307344
lDurationMean 0.906622
lDurationStd 0.155729
lDurationStdnorm 0.171768
lDurationMedian 0.895
lDurationQuartdelta 0.245
lDurationQuartdeltanorm 0.273743
lDurationKurt 2.68581
lDurationTrenddiff -0.1875
lDurationTrendratio 0.810127
lWidthMean 11.0739
lWidthStd 2.56915
lWidthStdnorm 0.232001
lWidthMedian 10.764
lWidthQuartdelta 3.01275
lWidthQuartdeltanorm 0.279891
lWidthKurt 5.54796
lWidthTrenddiff -1.989
lWidthTrendratio 0.834951
lHeightMean 28.1369
lHeightStd 5.92817
lHeightStdnorm 0.21069
lHeightMedian 29.601
lHeightQuartdelta 8.073
lHeightQuartdeltanorm 0.272727
lHeightKurt 2.94368
lHeightTrenddiff -4.2705
lHeightTrendratio 0.863806
lAspectMean 0.407196
lAspectStd 0.106836
lAspectStdnorm 0.26237
lAspectMedian 0.397887
lAspectQuartdelta 0.157497
lAspectQuartdeltanorm 0.395834
lAspectKurt 2.28928
lAspectTrenddiff 0.011888
lAspectTrendratio 1.03027
lSlantMean 0.184278
lSlantStd 0.099308
lSlantStdnorm 0.538904
lSlantMedian 0.180769
lSlantQuartdelta 0.110687
lSlantQuartdeltanorm 0.61231
lSlantKurt 2.93746
lSlantTrenddiff 0.0525972
lRtopMean 0.839731
lRtopStd 0.0800575
lRtopStdnorm 0.0953371
lRtopMedian 0.84375
lRtopQuartdelta 0.0830229
lRtopQuartdeltanorm 0.0983975
lRtopKurt 3.74957
lRtopTrenddiff 0.0627004
lRbotMean 0.396296
lRbotStd 0.162728
lRbotStdnorm 0.410621
lRbotMedian 0.375723
lRbotQuartdelta 0.178072
lRbotQuartdeltanorm 0.473946
lRbotKurt 3.6972
lRbotTrenddiff -0.0647849
lRrightMean 0.923812
lRrightStd 0.0359447
lRrightStdnorm 0.0389091
lRrightMedian 0.925466
lRrightQuartdelta 0.0545792
lRrightQuartdeltanorm 0.0589748
lRrightKurt 2.58513
lRrightTrenddiff 0.0246994
lRleftMean 0.304426
lRleftStd 0.129006
lRleftStdnorm 0.423767
lRleftMedian 0.304196
lRleftQuartdelta 0.149225
lRleftQuartdeltanorm 0.490557
lRleftKurt 3.39845
lRleftTrenddiff -0.0432521

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

FITTS Short Modified

meanTouchScore 0.749225
sumTouchScores 10.4891
meanMovementTime 1.27192
numTouches 14
undershootPercentage 0
overshootPercentage 35.7143

FITTS Long Modified

meanTouchScore 0.923077
sumTouchScores 12
meanMovementTime 1.6325
numTouches 13
undershootPercentage 7.69231
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 30.16
timePerZigzagCoV 0.0675677
timePerZigzagSlope 0.00782493
meanError 2.3525
tremorFreq 6.34766
tremorRelPower 32.4609
tremorGyroAmpMean 0.0759268
tremorGyroAmpSlope -0.000904907
tremorGyroAmpCoV 0.458353
tremorCoordAmpMean 0.0814921
tremorCoordAmpSlope 0.000273135
tremorCoordAmpCoV 0.349538
tremorAccAmpMean 0.0846032
tremorAccAmpSlope 0.000437371
tremorAccAmpCoV 0.261579
tremorPcRelVar 0.786902
tremorPcX -0.523438
tremorPcY 0.852064

ZigZag Segment 1

Duration 31.88 s, Accuracy Estimate 2.288 (lower is better)

ZigZag Segment 2

Duration 26.88 s, Accuracy Estimate 2.246 (lower is better)

ZigZag Segment 3

Duration 30.72 s, Accuracy Estimate 2.62 (lower is better)

ZigZag Segment 4

Duration 29.64 s, Accuracy Estimate 1.997 (lower is better)

ZigZag Segment 5

Duration 31.68 s, Accuracy Estimate 2.612 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 22.512
timePerZigzagCoV 0.185427
timePerZigzagSlope -0.110341
zigzagHeightMean 66.1016
zigzagHeightCoV 0.105008
zigzagHeightSlope -0.0531621
meanError 0.0441859
tremorFreq 6.25
tremorRelPower 36.9806
tremorGyroAmpMean 0.0714003
tremorGyroAmpSlope -0.00124653
tremorGyroAmpCoV 0.328444
tremorCoordAmpMean 0.0848112
tremorCoordAmpSlope -0.00110141
tremorCoordAmpCoV 0.306165
tremorAccAmpMean 0.104817
tremorAccAmpSlope 5.61666e-06
tremorAccAmpCoV 0.184586
tremorPcRelVar 0.829512
tremorPcX -0.609479
tremorPcY -0.792803

ZigZag Offset Segment 1

Duration 29.0 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 2

Duration 24.04 s, Accuracy Estimate 0.042 (lower is better)

ZigZag Offset Segment 3

Duration 20.56 s, Accuracy Estimate 0.04 (lower is better)

ZigZag Offset Segment 4

Duration 20.72 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 5

Duration 18.24 s, Accuracy Estimate 0.071 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.79}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.53}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9755263041421927}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.940284778726769}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6672511569026484}